This CLIC1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates, cell lysates or other biological fluids..
Applications
ELISA
Reactivity
Human
Sensitivity
0.123ng/mL
Detection Limit
0.312-20ng/mL
Note
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Product Properties
Storage Instruction
The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
tissue homogenates, cell lysates or other biological fluids.
Additional Info
Tissue Specificity
Expression is prominent in heart, placenta, liver, kidney and pancreas.
Post Translational Modifications
Hydrogen peroxide treatment causes a conformation change, leading to dimerization and formation of an intramolecular disulfide bond between Cys-24 and Cys-59.
Function
In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Reduces selenite and dehydroascorbate and may act as an antioxidant during oxidative stress response. Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Involved in regulation of the cell cycle.
Protein Name
Chloride Intracellular Channel Protein 1Chloride Channel AbpGlutaredoxin-Like Oxidoreductase Clic1Glutathione-Dependent Dehydroascorbate Reductase Clic1Nuclear Chloride Ion Channel 27Ncc27Regulatory Nuclear Chloride Ion Channel ProteinHrncc
Database Links
Cellular Localisation
NucleusNucleus MembraneSingle-Pass Membrane ProteinCytoplasmCell MembraneEndoplasmic ReticulumMostly In The Nucleus Including In The Nuclear MembraneSmall Amount In The Cytoplasm And The Plasma MembraneExists Both As Soluble Cytoplasmic Protein And As Membrane Protein With Probably A Single Transmembrane DomainMight Not Be Present In The Nucleus Of Cardiac Cells
