| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human Claudin-4-No tag protein was developed from hek293 cells and has a target region of No tag. For use in research applications. |
| Formulation: |
Supplied as 0.22 Mu m filtered solution in PBS (pH 7.4). Notice: If you need it for immunization, Do Not use any adjuvant. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Endotoxin: |
Less than 1EU per Mu g by the LAL method. |
| Immunoreactivity: |
Immobilized Human Claudin-4 VLP at 1 Mu g/ml (100 Mu l/well) on the plate. Dose response curve for Anti-Claudin 4 Antibody, hFc Tag with the EC50 of 18.4ng/ml determined by ELISA. |
| Gene Symbol: |
CLDN4 |
| Gene ID: |
1364 |
| Uniprot ID: |
CLD4_HUMAN |
| Immunogen Region: |
Met1-Val209 |
| Immunogen: |
Recombinant Human Claudin-4 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Val209) of human Claudin-4 (Accession #NP_001296.1) fused with no additional amino acid. |
| Function | Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. |
| Protein Name | Claudin-4Clostridium Perfringens Enterotoxin ReceptorCpe-RCpe-ReceptorWilliams-Beuren Syndrome Chromosomal Region 8 Protein |
| Database Links | Reactome: R-HSA-420029 |
| Cellular Localisation | Cell JunctionTight JunctionCell MembraneMulti-Pass Membrane ProteinCldn4 Is Required For Tight Junction Localization In The Kidney |
| Alternative Protein Names | Claudin-4 proteinClostridium Perfringens Enterotoxin Receptor proteinCpe-R proteinCpe-Receptor proteinWilliams-Beuren Syndrome Chromosomal Region 8 Protein proteinCLDN4 proteinCPER proteinCPETR1 proteinWBSCR8 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
