| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
32.6pg/mL |
| Detection Limit: |
78.1-5000pg/mL |
| Short Description: |
This CIRBP Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
CIRBP |
| Gene ID: |
1153 |
| Uniprot ID: |
CIRBP_HUMAN |
| Sample Type: |
serum, plasma, tissue homogenates or other biological fluids. |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Methylated on arginine residues. Methylation of the RGG motifs is a prerequisite for recruitment into SGs. Phosphorylated by CK2, GSK3A and GSK3B. Phosphorylation by GSK3B increases RNA-binding activity to the TXN 3'-UTR transcript upon exposure to UV radiation. |
| Function | Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor. Promotes assembly of stress granules (SGs), when overexpressed. |
| Protein Name | Cold-Inducible Rna-Binding ProteinA18 HnrnpGlycine-Rich Rna-Binding Protein Cirp |
| Database Links | |
| Cellular Localisation | NucleusNucleoplasmCytoplasmTranslocates From The Nucleus To The Cytoplasm After Exposure To Uv RadiationTranslocates From The Nucleus To The Cytoplasm Into Stress Granules Upon Various Cytoplasmic StressesSuch As Osmotic And Heat ShocksIts Recruitment Into Stress Granules Occurs In The Absence Of Tiar Proteins |
| Alternative ELISA Names | Cold-Inducible Rna-Binding Protein ELISA kitA18 Hnrnp ELISA kitGlycine-Rich Rna-Binding Protein Cirp ELISA kitCIRBP ELISA kitA18HNRNP ELISA kitCIRP ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
