Human CEA/CD66e protein (Recombinant) (C-His) (STJP001168)

Human CEA/CD66e protein (Recombinant) (C-His) (STJP001168)

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STJP001168
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Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 0.1 EU/Mu g of the protein by LAL method.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human CEACAM5 at 5 Mu g/mL (100 Mu L/well) can bind Recombinant Human CEACAM8 with a linear range of 0.5-3 Mu g/mL.
Gene Symbol: CEACAM5
Gene ID: 1048
Uniprot ID: CEAM5_HUMAN
Immunogen: Recombinant Human CEA/CD66e Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Lys35-Ala685) of human CEACAM-5/CD66e (Accession #NP_004354.2) fused with a 6×His tag at the C-terminus.
Immunogen Sequence: KLTIESTPFNVAEGKEVLLL VHNLPQHLFGYSWYKGERVD GNRQIIGYVIGTQQATPGPA YSGREIIYPNASLLIQNIIQ NDTGFYTLHVIKSDLVNEEA TGQFRVYPELPKPSISSNNS KPVEDKDAVAFTCEPETQDA TYLWWVNNQSLPVSPRLQLS NGNRTLTLFNVTRNDTASYK CETQNPVSARRSDSVILNVL YGPDAPTISPLNTSYRSGEN LNLSCHAASNPPAQYSWFV
Post Translational Modifications Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.
Function Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Plays a role as an oncogene by promoting tumor progression.induces resistance to anoikis of colorectal carcinoma cells. (Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.
Protein Name Cell Adhesion Molecule Ceacam5
Carcinoembryonic Antigen
Cea
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5
Cea Cell Adhesion Molecule 5
Meconium Antigen 100
Cd Antigen Cd66e
Database Links Reactome: R-HSA-163125
Reactome: R-HSA-202733
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Apical Cell Membrane
Cell Surface
Localized To The Apical Glycocalyx Surface
Alternative Protein Names Cell Adhesion Molecule Ceacam5 protein
Carcinoembryonic Antigen protein
Cea protein
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 protein
Cea Cell Adhesion Molecule 5 protein
Meconium Antigen 100 protein
Cd Antigen Cd66e protein
CEACAM5 protein
CEA protein

Information sourced from Uniprot.org

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