• Human CDCP1 (CUB Domain Containing Protein 1) Sandwich ELISA Kit (STJE0007831)

Human CDCP1 (CUB Domain Containing Protein 1) Sandwich ELISA Kit (STJE0007831)

SKU:
STJE0007831

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.127ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This CDCP1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: CDCP1
Gene ID: 64866
Uniprot ID: CDCP1_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Highly expressed in mitotic cells with low expression during interphase. Detected at highest levels in skeletal muscle and colon with lower levels in kidney, small intestine, placenta and lung. Up-regulated in a number of human tumor cell lines, as well as in colorectal cancer, breast carcinoma and lung cancer. Also expressed in cells with phenotypes reminiscent of mesenchymal stem cells and neural stem cells.
Post Translational Modifications Phosphorylated on tyrosine by kinases of the SRC family such as SRC and YES as well as by the protein kinase C gamma/PRKCG. Dephosphorylated by phosphotyrosine phosphatases. Also phosphorylated by suramin, a heparin analog. Tyrosine phosphorylated in response to dissociation of integrin alpha-6 beta-4 from laminin-5. N-glycosylated. A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding). Another peptide of 80 kDa (p80) is present in cultured keratinocytes probably due to tryptic cleavage at an unidentified site on its N-terminal side. Converted to p80 by plasmin, a trypsin-like protease.
Function May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis.
Protein Name Cub Domain-Containing Protein 1
Membrane Glycoprotein Gp140
Subtractive Immunization M Plus Hep3-Associated 135 Kda Protein
Sima135
Transmembrane And Associated With Src Kinases
Cd Antigen Cd318
Database Links
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Membrane Protein
Shedding May Also Lead To A Soluble Peptide
Isoform 3: Secreted
Alternative ELISA Names Cub Domain-Containing Protein 1 ELISA kit
Membrane Glycoprotein Gp140 ELISA kit
Subtractive Immunization M Plus Hep3-Associated 135 Kda Protein ELISA kit
Sima135 ELISA kit
Transmembrane And Associated With Src Kinases ELISA kit
Cd Antigen Cd318 ELISA kit
CDCP1 ELISA kit
TRASK ELISA kit
UNQ2486 ELISA kit
PRO5773 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance