• Human CD63 protein (Recombinant) (C-His) (STJP001824)

Human CD63 protein (Recombinant) (C-His) (STJP001824)

SKU:
STJP001824

£78.50 - £302.50
Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human CD63-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CD63
Gene ID: 967
Uniprot ID: CD63_HUMAN
Immunogen Region: Ala103-Val203
Immunogen: Recombinant Human CD63 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala103-Val203) of human CD63 (Accession #NP_001771.1) fused with a 6×His tag at the C-terminus.
Post Translational Modifications Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro).
Function Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
Protein Name Cd63 Antigen
Granulophysin
Lysosomal-Associated Membrane Protein 3
Lamp-3
Lysosome Integral Membrane Protein 1
Limp1
Melanoma-Associated Antigen Me491
Oma81h
Ocular Melanoma-Associated Antigen
Tetraspanin-30
Tspan-30
Cd Antigen Cd63
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Lysosome Membrane
Late Endosome Membrane
Endosome
Multivesicular Body
Melanosome
Secreted
Extracellular Exosome
Cell Surface
Also Found In Weibel-Palade Bodies Of Endothelial Cells
Located In Platelet Dense Granules
Detected In A Subset Of Pre-Melanosomes
Detected On Intralumenal Vesicles (Ilvs) Within Multivesicular Bodies
Alternative Protein Names Cd63 Antigen protein
Granulophysin protein
Lysosomal-Associated Membrane Protein 3 protein
Lamp-3 protein
Lysosome Integral Membrane Protein 1 protein
Limp1 protein
Melanoma-Associated Antigen Me491 protein
Oma81h protein
Ocular Melanoma-Associated Antigen protein
Tetraspanin-30 protein
Tspan-30 protein
Cd Antigen Cd63 protein
CD63 protein
MLA1 protein
TSPAN30 protein

Information sourced from Uniprot.org

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