| Function | Member of the immunoglobulin superfamily (IgSF) that links tetraspanin-enriched microdomains to the actin cytoskeleton and plays several important roles in innate and adaptive immunity. Acts as an inducible receptor of HSPA8 on dendritic cells to enhance the CCL21/SLC-dependent migration of activated mature dendritic cells while attenuating their antigen-specific stimulatory capacities. In complex with alpha-actinins ACTN1 and ACTN4, regulates actin dynamics in the immune synapse and subsequent T-cell activation. Inhibits the entry of several viruses such as hepatitis C Virus (HCV) or HIV-1. Mechanistically, promotes a change in CD81 organization at the plasma membrane by significantly restricting its diffusion which in turn influences CD81 interaction with Claudin-1/CLDN1, preventing CLDN1 from acting as a co-receptor required for HCV entry. Accumulates at the presynaptic terminal, the producer cell side of the virological synapse, to prevent HIV-1 Env-mediated cell-cell fusion. Highly expressed on malignant cells with antigen presentation defects, interacts with NK receptor KIR3DL2 to suppress NK-cell cytotoxicity. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain. |
| Protein Name | Immunoglobulin Superfamily Member 8Igsf8Cd81 Partner 3Glu-Trp-Ile Ewi Motif-Containing Protein 2Ewi-2Keratinocytes-Associated Transmembrane Protein 4Kct-4Lir-D1Prostaglandin Regulatory-Like ProteinPgrlCd Antigen Cd316 |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinColocalizes With Cd81 At The Immune Synapse |
| Alternative Protein Names | Immunoglobulin Superfamily Member 8 proteinIgsf8 proteinCd81 Partner 3 proteinGlu-Trp-Ile Ewi Motif-Containing Protein 2 proteinEwi-2 proteinKeratinocytes-Associated Transmembrane Protein 4 proteinKct-4 proteinLir-D1 proteinProstaglandin Regulatory-Like Protein proteinPgrl proteinCd Antigen Cd316 proteinIGSF8 proteinCD81P3 proteinEWI2 proteinKCT4 protein |
Information sourced from Uniprot.org
