Function | Receptor on natural killer (NK) cells and T cells for MHC class I molecules. Upon binding of peptide-free HLA-F open conformer, negatively regulates NK and T cell effector functions. Acts as a receptor on astrocytes for HLA-F. Through interaction with HLA-F, may protect motor neurons from astrocyte-induced toxicity. |
Protein Name | Killer Cell Immunoglobulin-Like Receptor 3dl2Cd158 Antigen-Like Family Member KNatural Killer-Associated Transcript 4Nkat-4P70 Natural Killer Cell Receptor Clone Cl-5P70 Nk Receptor Cl-5Cd Antigen Cd158k |
Database Links | Reactome: R-HSA-198933 |
Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
Alternative Protein Names | Killer Cell Immunoglobulin-Like Receptor 3dl2 proteinCd158 Antigen-Like Family Member K proteinNatural Killer-Associated Transcript 4 proteinNkat-4 proteinP70 Natural Killer Cell Receptor Clone Cl-5 proteinP70 Nk Receptor Cl-5 proteinCd Antigen Cd158k proteinKIR3DL2 proteinCD158K proteinNKAT4 protein |
Information sourced from Uniprot.org