• Human CD10/MME protein (Recombinant) (C-His) (STJP002446)

Human CD10/MME protein (Recombinant) (C-His) (STJP002446)

SKU:
STJP002446-50

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Host: HEK293 Cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human CD10/MME-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of 20mM MES, 100mM NaCl, 1mM ZnCl2, 10%Glycerol, pH 6.5.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity: Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPPGFSAFK (Dnp)-OH, (R&D Systems, Catalog # ES005). The specific activity is >1, 500 pmoles/min/Mu g.
Gene Symbol: MME
Gene ID: 4311
Uniprot ID: NEP_HUMAN
Immunogen Region: Tyr52-Trp750
Immunogen: Recombinant Human CD10/MME Protein is produced by HEK293 Cells expression system. The target protein is expressed with sequence (Tyr52-Trp750) of human CD10/MME (Accession #NP_000893.2) fused with a 6×His tag at the C-terminus.
Function Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Catalyzes cleavage of bradykinin, substance P and neurotensin peptides. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF) and brain natriuretic factor (BNP(1-32)). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers.
Protein Name Neprilysin
Atriopeptidase
Common Acute Lymphocytic Leukemia Antigen
Calla
Enkephalinase
Neutral Endopeptidase 24.11
Nep
Neutral Endopeptidase
Skin Fibroblast Elastase
Sfe
Cd Antigen Cd10
Database Links Reactome: R-HSA-2022377
Reactome: R-HSA-5578768
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Alternative Protein Names Neprilysin protein
Atriopeptidase protein
Common Acute Lymphocytic Leukemia Antigen protein
Calla protein
Enkephalinase protein
Neutral Endopeptidase 24.11 protein
Nep protein
Neutral Endopeptidase protein
Skin Fibroblast Elastase protein
Sfe protein
Cd Antigen Cd10 protein
MME protein
EPN protein

Information sourced from Uniprot.org

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