| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human CCL13/MCP-4-C-hFc protein was developed from hek293 cells and has a target region of C-hFc. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CCL13 |
| Gene ID: |
6357 |
| Uniprot ID: |
CCL13_HUMAN |
| Immunogen Region: |
Gln24-Thr98 |
| Immunogen: |
Recombinant Human CCL13/MCP-4 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln24-Thr98) of human CCL13/MCP-4 (Accession #NP_005399.1) fused with and a hFc tag at the C-terminus. |
| Post Translational Modifications | One major form (form long), and two minor forms (short chain and medium chain) are produced by differential signal peptide cleavage. The medium chain is about 30-fold less active than the long chain. |
| Function | Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens. |
| Protein Name | C-C Motif Chemokine 13Ck-Beta-10Monocyte Chemoattractant Protein 4Monocyte Chemotactic Protein 4Mcp-4Ncc-1Small-Inducible Cytokine A13 Cleaved Into - C-C Motif Chemokine 13 - Long Chain - C-C Motif Chemokine 13 - Medium Chain - C-C Motif Chemokine 13 - Short Chain |
| Database Links | Reactome: R-HSA-380108Reactome: R-HSA-418594 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | C-C Motif Chemokine 13 proteinCk-Beta-10 proteinMonocyte Chemoattractant Protein 4 proteinMonocyte Chemotactic Protein 4 proteinMcp-4 proteinNcc-1 proteinSmall-Inducible Cytokine A13 Cleaved Into - C-C Motif Chemokine 13 - Long Chain - C-C Motif Chemokine 13 - Medium Chain - C-C Motif Chemokine 13 - Short Chain proteinCCL13 proteinMCP4 proteinNCC1 proteinSCYA13 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
