• Human CACNa1B (Calcium Channel, Voltage Dependent, N-Type, Alpha 1B Subunit) Sandwich ELISA Kit (STJE0007632)

Human CACNa1B (Calcium Channel, Voltage Dependent, N-Type, Alpha 1B Subunit) Sandwich ELISA Kit (STJE0007632)

SKU:
STJE0007632

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.129ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This CACNa1B Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: CACNA1B
Gene ID: 774
Uniprot ID: CAC1B_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Isoform Alpha-1b-1 and isoform Alpha-1b-2 are expressed in the central nervous system, but not in skeletal muscle or aorta. Expressed in the cerebral white matter, cortex, hippocampus, basal ganglia, and cerebellum.
Post Translational Modifications Phosphorylated in vitro by CaM-kinase II, PKA, PKC and CGPK.
Function Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group. They are involved in pain signaling. Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. Mediates Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals.
Protein Name Voltage-Dependent N-Type Calcium Channel Subunit Alpha-1b
Brain Calcium Channel Iii
Biii
Calcium Channel - L Type - Alpha-1 Polypeptide Isoform 5
Voltage-Gated Calcium Channel Subunit Alpha Cav2.2
Database Links Reactome: R-HSA-112308
Cellular Localisation Membrane
Multi-Pass Membrane Protein
Alternative ELISA Names Voltage-Dependent N-Type Calcium Channel Subunit Alpha-1b ELISA kit
Brain Calcium Channel Iii ELISA kit
Biii ELISA kit
Calcium Channel - L Type - Alpha-1 Polypeptide Isoform 5 ELISA kit
Voltage-Gated Calcium Channel Subunit Alpha Cav2.2 ELISA kit
CACNA1B ELISA kit
CACH5 ELISA kit
CACNL1A5 ELISA kit
output

Information sourced from Uniprot.org

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