• Human BIRC6 (Baculoviral IAP Repeat Containing Protein 6) Sandwich ELISA Kit (STJE0007479)

Human BIRC6 (Baculoviral IAP Repeat Containing Protein 6) Sandwich ELISA Kit (STJE0007479)

SKU:
STJE0007479

£329.50 - £631.50
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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.107ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This BIRC6 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: BIRC6
Gene ID: 57448
Uniprot ID: BIRC6_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Expressed in brain cancer cells.
Post Translational Modifications Ubiquitinated. Ubiquitination is mediated by the RNF41 E3 ligase and leads to proteasomal degradation, impairing inhibition of apoptosis. Deubiquitinated by USP8/UBPY.
Function Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its targets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification.
Protein Name Baculoviral Iap Repeat-Containing Protein 6
Bir Repeat-Containing Ubiquitin-Conjugating Enzyme
Bruce
Ring-Type E3 Ubiquitin Transferase Birc6
Ubiquitin-Conjugating Bir Domain Enzyme Apollon
Apollon
Database Links Reactome: R-HSA-9700645
Reactome: R-HSA-9725370
Cellular Localisation Golgi Apparatus
Trans-Golgi Network Membrane
Endosome
Cytoplasm
Cytoskeleton
Spindle Pole
Microtubule Organizing Center
Centrosome
Midbody
Midbody Ring
Exhibits Cell Cycle-Dependent Localization
Concentrates In A Pericentriolar Compartment In Interphase
Moves Partially To Spindle Poles In Metaphase
And Finally Localizes To The Spindle Midzone And The Midbody In Telophase And During Cytokinesis
On The Midbody
Localizes To The Midbody Ring
Also Called Flemming Body
In Interphase Cells
Localizes To The Trans-Golgi Network Membrane And Endosomes
During Cytokinesis
A Fraction Moves To The Midzone Where It Specifically Arrives At The Midbody Ring
After Abscission Completion
Travels With The Midbody Remnant Into One Daughter Cell
And Remains Bound To It Until A New Midbody Ring Is Formed During The Next Cell Division
Alternative ELISA Names Baculoviral Iap Repeat-Containing Protein 6 ELISA kit
Bir Repeat-Containing Ubiquitin-Conjugating Enzyme ELISA kit
Bruce ELISA kit
Ring-Type E3 Ubiquitin Transferase Birc6 ELISA kit
Ubiquitin-Conjugating Bir Domain Enzyme Apollon ELISA kit
Apollon ELISA kit
BIRC6 ELISA kit
KIAA1289 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance