| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.112ng/mL |
| Detection Limit: |
0.312-20ng/mL |
| Short Description: |
This BIN2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
3 hrs |
| Gene Symbol: |
BIN2 |
| Gene ID: |
51411 |
| Uniprot ID: |
BIN2_HUMAN |
| Immunogen Region: |
Ready-To-Use |
| Sample Type: |
tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | Detected in natural killer cells (at protein level). Highest level expression seen in spleen and peripheral blood leukocytes and is also expressed at high levels in thymus, colon and placenta, suggesting preferential expression in hematopoietic tissues. |
| Post Translational Modifications | |
| Function | Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. |
| Protein Name | Bridging Integrator 2Breast Cancer-Associated Protein 1 |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-9673768 |
| Cellular Localisation | CytoplasmCell ProjectionPodosome MembranePeripheral Membrane ProteinCytoplasmic SideCell CortexPhagocytic CupAssociates With Membranes Enriched In PhosphoinositidesDetected In The Actin-Rich Cell Cortex At The Leading Edge Of Migrating CellsDetected At PodosomesAt An Actin-Rich Ring-Like Structure |
| Alternative ELISA Names | Bridging Integrator 2 ELISA kitBreast Cancer-Associated Protein 1 ELISA kitBIN2 ELISA kitBRAP1 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
