Human BID protein (Recombinant) (N-His) (STJP004976)

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STJP004976
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human BID-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: BID
Gene ID: 637
Uniprot ID: BID_HUMAN
Immunogen Region: Met1-Asp195
Immunogen: Homo sapiens (Human)
Post Translational Modifications BH3-interacting domain death agonist: TNF-alpha induces caspase-mediated cleavage into a major p15 and minor p13 and p11 products. Cleaved by CASP6 into a major p15 and minor p13 products, leading to release of cytochrome c and subsequent nonalcoholic steatohepatitis. BH3-interacting domain death agonist p15: Ubiquitinated by ITCH.ubiquitination results in proteasome-dependent degradation.
Function Induces caspases and apoptosis. Counters the protective effect of BCL2. BH3-interacting domain death agonist p15: Induces caspase activation and apoptosis. Allows the release of cytochrome c. Isoform 1: Induces ICE-like proteases and apoptosis. Isoform 2: Induces ICE-like proteases and apoptosis. Isoform 3: Does not induce apoptosis. Isoform 4: Induces ICE-like proteases and apoptosis.
Protein Name Bh3-Interacting Domain Death Agonist
P22 Bid
Bid Cleaved Into - Bh3-Interacting Domain Death Agonist P15
P15 Bid - Bh3-Interacting Domain Death Agonist P13
P13 Bid - Bh3-Interacting Domain Death Agonist P11
P11 Bid
Database Links Reactome: R-HSA-111447
Reactome: R-HSA-111452
Reactome: R-HSA-111453
Reactome: R-HSA-114294
Reactome: R-HSA-6803204
Reactome: R-HSA-75108
Cellular Localisation Cytoplasm
Mitochondrion Membrane
Mitochondrion Outer Membrane
When Uncleaved
It Is Predominantly Cytoplasmic
Bh3-Interacting Domain Death Agonist P15: Mitochondrion Membrane
Translocates To Mitochondria As An Integral Membrane Protein
Bh3-Interacting Domain Death Agonist P13: Mitochondrion Membrane
Associated With The Mitochondrial Membrane
Isoform 1: Cytoplasm
Isoform 3: Cytoplasm
Isoform 2: Mitochondrion Membrane
A Significant Proportion Of Isoform 2 Localizes To Mitochondria
It May Be Cleaved Constitutively
Alternative Protein Names Bh3-Interacting Domain Death Agonist protein
P22 Bid protein
Bid Cleaved Into - Bh3-Interacting Domain Death Agonist P15 protein
P15 Bid - Bh3-Interacting Domain Death Agonist P13 protein
P13 Bid - Bh3-Interacting Domain Death Agonist P11 protein
P11 Bid protein
BID protein

Information sourced from Uniprot.org

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