• Human ATG12 (Autophagy Related Protein 12) Sandwich ELISA Kit (STJE0007362)

Human ATG12 (Autophagy Related Protein 12) Sandwich ELISA Kit (STJE0007362)

SKU:
STJE0007362

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.057ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This ATG12 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: ATG12
Gene ID: 9140
Uniprot ID: ATG12_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Ubiquitous.
Post Translational Modifications Acetylated by EP300.
Function Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. (Microbial infection) May act as a proviral factor. In association with ATG5, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection. Required for the translation of incoming hepatitis C virus (HCV) RNA and, thereby, for the initiation of HCV replication, but not required once infection is established.
Protein Name Ubiquitin-Like Protein Atg12
Autophagy-Related Protein 12
Apg12-Like
Database Links Reactome: R-HSA-1632852
Reactome: R-HSA-5205685
Reactome: R-HSA-8934903
Reactome: R-HSA-936440
Cellular Localisation Cytoplasm
Preautophagosomal Structure Membrane
Peripheral Membrane Protein
Tecpr1 Recruits The Atg12-Atg5 Conjugate To The Autolysosomal Membrane
Alternative ELISA Names Ubiquitin-Like Protein Atg12 ELISA kit
Autophagy-Related Protein 12 ELISA kit
Apg12-Like ELISA kit
ATG12 ELISA kit
APG12 ELISA kit
APG12L ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance