| Post Translational Modifications | Phosphorylated.phosphorylation enhances the F-actin bundling activity. Phosphorylated by GSK3B. Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is facilitated by Axin. Deubiquitinated by ZRANB1/TRABID. |
| Function | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton. Plays a role in mediating the organization of F-actin into ordered bundles. Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. |
| Protein Name | Adenomatous Polyposis Coli ProteinProtein ApcDeleted In Polyposis 2.5 |
| Database Links | Reactome: R-HSA-111465Reactome: R-HSA-195253Reactome: R-HSA-196299Reactome: R-HSA-3769402Reactome: R-HSA-4641262Reactome: R-HSA-5339716Reactome: R-HSA-5358747Reactome: R-HSA-5358749Reactome: R-HSA-5358751Reactome: R-HSA-5358752Reactome: R-HSA-5467333Reactome: R-HSA-5467337Reactome: R-HSA-5467340Reactome: R-HSA-5467348Reactome: R-HSA-5689896 |
| Cellular Localisation | Cell JunctionAdherens JunctionCytoplasmCytoskeletonCell ProjectionLamellipodiumRuffle MembraneCell MembraneAssociated With The Microtubule Network At The Growing Distal Tip Of MicrotubulesMapre1 May Be Required For Targeting To The Growing Microtubule Plus EndsAccumulates In The Lamellipodium And Ruffle Membrane In Response To Hepatocyte Growth Factor (Hgf) TreatmentThe Memo1-Rhoa-Diaph1 Signaling Pathway Controls Localization Of The Phosphorylated Form To The Cell Membrane |
| Alternative Protein Names | Adenomatous Polyposis Coli Protein proteinProtein Apc proteinDeleted In Polyposis 2.5 proteinAPC proteinDP2.5 protein |
Information sourced from Uniprot.org
