Human AOX1 protein (Recombinant) (N-His) (STJP008224)

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STJP008224
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human AOX1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: AOX1
Gene ID: 316
Uniprot ID: AOXA_HUMAN
Immunogen Region: Met1-Lys166
Immunogen: Homo sapiens (Human)
Function Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. May also catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis.
Protein Name Aldehyde Oxidase
Aldehyde Oxidase 1
Azaheterocycle Hydroxylase
Database Links Reactome: R-HSA-964975
Cellular Localisation Cytoplasm
Alternative Protein Names Aldehyde Oxidase protein
Aldehyde Oxidase 1 protein
Azaheterocycle Hydroxylase protein
AOX1 protein
AO protein

Information sourced from Uniprot.org

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