Name: Human ALK-1/ACVRL1 protein (Recombinant) (C-His) (STJP001078)
SKU: STJP001078
Availability: InStock

Human ALK-1/ACVRL1 protein (Recombinant) (C-His) (STJP001078)

SKU:

STJP001078

$87.08 - $303.08

Host:	HEK293 cells
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Formulation:	Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method:	Please contact us for more information.
Immunoreactivity:	Measured by its binding ability in a functional ELISA. Immobilized Human ALK-1 at 4 Mu g/mL (100 Mu L/well) can bind Human ACVR2B with a linear range of 0.08-2.4 Mu g/mL.

Gene Symbol:	ACVRL1
Gene ID:	94
Uniprot ID:	ACVL1_HUMAN
Immunogen:	Recombinant Human ALK-1 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Asp22-Gln118) of human ALK-1 (Accession #NP_000011.2) fused with a 6×His tag at the C-terminus.
Immunogen Sequence:	DPVKPSRGPLVTCTCESPHC KGPTCRGAWCTVVLVREEGR HPQEHRGCGNLHRELCRGRP TEFVNHYCCDSHLCNHNVSL VLEATQPPSEQPGTDGQ

Function	Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.
Protein Name	Activin Receptor Type-1-Like Activin Receptor-Like Kinase 1 Alk-1 Serine/Threonine-Protein Kinase Receptor R3 Skr3 Tgf-B Superfamily Receptor Type I Tsr-I
Database Links	Reactome: R-HSA-201451
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein
Alternative Protein Names	Activin Receptor Type-1-Like protein Activin Receptor-Like Kinase 1 protein Alk-1 protein Serine/Threonine-Protein Kinase Receptor R3 protein Skr3 protein Tgf-B Superfamily Receptor Type I protein Tsr-I protein ACVRL1 protein ACVRLK1 protein ALK1 protein

Information sourced from Uniprot.org

Model	Name	Host
STJP002758	Human TGFR-1/ALK-5 protein (Recombinant) (C-hFc & His) (STJP002758)	HEK293 cells
STJP001023	Human ALK-7/ACVR1C protein (Recombinant) (C-hFc&His) (STJP001023)	HEK293 cells
STJP002553	Human ALK-4/ACVR1B protein (Recombinant) (C-hFc & his) (STJP002553)	HEK293 cells
STJP001235	Human BMPR-1B/ALK-6 protein (Recombinant) (C-hFc&His) (STJP001235)	HEK293 cells
STJP000931	Human BMPR-1A/ALK-3 protein (Recombinant) (C-hFc&His) (STJP000931)	HEK293 cells
STJP001333	Human TIMP-1 protein (Recombinant) (C-His) (STJP001333)	HEK293 cells
STJP001340	Human Dkk-1 protein (Recombinant) (C-His) (STJP001340)	HEK293 cells
STJP002478	Human ENPP-1 protein (Recombinant) (C-His) (STJP002478)	HEK293 cells

Human ALK-1/ACVRL1 protein (Recombinant) (C-His) (STJP001078)