| Short Description : | Recombinant-Human ALK-1/ACVRL1-C-His protein was developed in hek293 cells using the region Asp22-Gln118. For use in research applications. |
| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: | Measured by its binding ability in a functional ELISA. Immobilized Human ALK-1 at 4 Mu g/mL (100 Mu L/well) can bind Human ACVR2B with a linear range of 0.08-2.4 Mu g/mL. |
| Determination Method: | Please contact us for more information. |
| Gene Symbol: | ACVRL1 |
| Gene ID: | 94 |
| Uniprot ID: | ACVL1_HUMAN |
| Immunogen: | Recombinant Human ALK-1 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Asp22-Gln118) of human ALK-1 (Accession #NP_000011.2) fused with a 6×His tag at the C-terminus. |
| Immunogen Region: | Asp22-Gln118 |
| Immunogen Sequence: | DPVKPSRGPLVTCTCESPHC KGPTCRGAWCTVVLVREEGR HPQEHRGCGNLHRELCRGRP TEFVNHYCCDSHLCNHNVSL VLEATQPPSEQPGTDGQ |
| Function | Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well. |
| Protein Name | Activin Receptor Type-1-LikeActivin Receptor-Like Kinase 1Alk-1Serine/Threonine-Protein Kinase Receptor R3Skr3Tgf-B Superfamily Receptor Type ITsr-I |
| Database Links | Reactome: R-HSA-201451 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Activin Receptor Type-1-Like proteinActivin Receptor-Like Kinase 1 proteinAlk-1 proteinSerine/Threonine-Protein Kinase Receptor R3 proteinSkr3 proteinTgf-B Superfamily Receptor Type I proteinTsr-I proteinACVRL1 proteinACVRLK1 proteinALK1 protein |
Information sourced from Uniprot.org
