• Human ADAM15 (A Disintegrin And Metalloprotease 15) Sandwich ELISA Kit (STJE0006887)

Human ADAM15 (A Disintegrin And Metalloprotease 15) Sandwich ELISA Kit (STJE0006887)

SKU:
STJE0006887

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.054ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This ADAM15 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: ADAM15
Gene ID: 8751
Uniprot ID: ADA15_HUMAN
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity Expressed in colon and small intestine. Expressed in airway smooth muscle and glomerular mesangial cells (at protein level). Ubiquitously expressed. Overexpressed in atherosclerotic lesions. Constitutively expressed in cultured endothelium and smooth muscle. Expressed in chondrocytes. Expressed in airway smooth muscle and glomerular mesangial cells.
Post Translational Modifications The precursor is cleaved by a furin endopeptidase. Phosphorylation increases association with PTKs.
Function Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain.
Protein Name Disintegrin And Metalloproteinase Domain-Containing Protein 15
Adam 15
Metalloprotease Rgd Disintegrin Protein
Metalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich Protein 15
Mdc-15
Metargidin
Database Links Reactome: R-HSA-1474228
Reactome: R-HSA-8941237
Cellular Localisation Endomembrane System
Single-Pass Type I Membrane Protein
Cell Junction
Adherens Junction
Cell Projection
Cilium
Flagellum
Cytoplasmic Vesicle
Secretory Vesicle
Acrosome
The Majority Of The Protein Is Localized In A Perinuclear Compartment Which May Correspond To The Trans-Golgi Network Or The Late Endosome
The Pro-Protein Is The Major Detectable Form On The Cell Surface
Whereas The Majority Of The Protein In The Cell Is Processed
Alternative ELISA Names Disintegrin And Metalloproteinase Domain-Containing Protein 15 ELISA kit
Adam 15 ELISA kit
Metalloprotease Rgd Disintegrin Protein ELISA kit
Metalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich Protein 15 ELISA kit
Mdc-15 ELISA kit
Metargidin ELISA kit
ADAM15 ELISA kit
MDC15 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance