• Human ABCA3 (ATP Binding Cassette Transporter A3) Sandwich ELISA Kit Ready-To-Use (STJE0013190)

Human ABCA3 (ATP Binding Cassette Transporter A3) Sandwich ELISA Kit Ready-To-Use (STJE0013190)

SKU:
STJE0013190

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 29pg/mL
Detection Limit: 78.1-5000pg/mL
Short Description: This ABCA3 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: ABCA3
Gene ID: 21
Uniprot ID: ABCA3_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Expressed in brain, pancreas, skeletal muscle and heart. Highly expressed in the lung in an AT2-cell-specific manner. Weakly expressed in placenta, kidney and liver. Also expressed in medullary thyroid carcinoma cells (MTC) and in C-cell carcinoma.
Post Translational Modifications N-glycosylated. Localization at intracellular vesicles is accompanied by processing of oligosaccharide from high mannose type to complex type. N-linked glycosylation at Asn-124 and Asn-140 is required for stability and efficient anterograde trafficking and prevents from proteasomal degradation. Proteolytically cleaved by CTSL and to a lower extent by CTSB within multivesicular bodies (MVB) and lamellar bodies (LB) leading to a mature form of 150 kDa.
Function Catalyzes the ATP-dependent transport of phospholipids such as phosphatidylcholine and phosphoglycerol from the cytoplasm into the lumen side of lamellar bodies, in turn participates in the lamellar bodies biogenesis and homeostasis of pulmonary surfactant. Transports preferentially phosphatidylcholine containing short acyl chains. In addition plays a role as an efflux transporter of miltefosine across macrophage membranes and free cholesterol (FC) through intralumenal vesicles by removing FC from the cell as a component of surfactant and protects cells from free cholesterol toxicity.
Protein Name Phospholipid-Transporting Atpase Abca3
Abc-C Transporter
Atp-Binding Cassette Sub-Family A Member 3
Atp-Binding Cassette Transporter 3
Atp-Binding Cassette 3
Xenobiotic-Transporting Atpase Abca3 Cleaved Into - 150 Kda Mature Form
Database Links Reactome: R-HSA-1369062
Reactome: R-HSA-5683678
Reactome: R-HSA-5683826
Reactome: R-HSA-5688399
Cellular Localisation Endosome
Multivesicular Body Membrane
Multi-Pass Membrane Protein
Cytoplasmic Vesicle Membrane
Late Endosome Membrane
Lysosome Membrane
Localized In The Limiting Membrane Of Lamellar Bodies In Lung Alveolar Type Ii Cells
Trafficks Via The Golgi
Sorting Vesicles (Svs) And Late Endosome/Multivesicular Body Network Directly To The Outer Membrane Of Lamellar Bodies In At2 Lung Epithelial Cells Or To Lysosomes And Lysosomal-Related Organelles (Lros) In Other Cells Where Undergoes Proteolytic Cleavage And Oligosaccharide Processing From High Mannose Type To Complex Type
Oligomers Formation Takes Place In A Post-Endoplasmic Reticulum Compartment
Alternative ELISA Names Phospholipid-Transporting Atpase Abca3 ELISA kit
Abc-C Transporter ELISA kit
Atp-Binding Cassette Sub-Family A Member 3 ELISA kit
Atp-Binding Cassette Transporter 3 ELISA kit
Atp-Binding Cassette 3 ELISA kit
Xenobiotic-Transporting Atpase Abca3 Cleaved Into - 150 Kda Mature Form ELISA kit
ABCA3 ELISA kit
ABC3 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance