Trial size COX4I1 antibodies available in the Antibody Validation Project

Posted by M.Popov on 12th Nov 2020

Trial size COX4I1 antibodies available in the Antibody Validation Project

Trial size COX4I1 antibodies available in the Antibody Validation Project

Introduction:

Cytochrome c oxidase subunit 4I1 is the protein produced by the COX4I1 gene. This enzyme is the terminal enzyme of the mitochondrial respiratory chain and contributes to proton electrochemical gradient across the inner mitochondrial membrane. Furthermore, diseases related to mutations of this gene are several nervous disorders, excess bone growth and skin diseases and it can also be used as a prognostic marker in favourable renal cancer. We provide a number of trial sized antibodies, which are suitable for COX4I1 research purposes, and to help you make the right decision and find the best suited antibody for you, please find the answers to some of the key topics regarding COX4I1 that we have provided in the links below.

What is COX4I1?

Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits, which perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it.

Where is COX4I1 found?

Inside the cell, COX4I1 is detected in the mitochondria and it has cytoplasmic expression with a granular pattern in most tissues.

What role does COX4I1 play in disease?

Mutations in this gene lead not only to several cancers, but also to nervous system and bone diseases. Neuronal ceroid lipofuscinosis is a disease affecting the nervous system, closely related to COX4I1 and another linked disorder is Calvarial hyperostosis, a benign X-linked disorder that affects only the skull.

COX4I1 antibodies in the Antibody Validation project

St John's Laboratory offers a variety of trial size primary antibodies which target COX4I1, which are available to try through the Antibody Validation Project. Below we highlight those which have already been reviewed, as well as others which are available to try.

Customer reviewed COX4I1 antibodies

ModelNameHostClonalityRatingApplication Tested
STJ96935Anti-COX IV antibodyMouseMonoclonal4IF

Other COX4I1 antibodies available in the Antibody Validation Project

ModelNameHostClonalityRecommended Applications
STJ92439Anti-COX4 antibodyRabbitPolyclonalWB,IHC,IF,ELISA
STJ97964Anti-COX4 antibodyMouseMonoclonalWB,IF,FC,ELISA
STJ99044Anti-COX IV antibodyMouseMonoclonalWB,ELISA
ModelNameHostClonalityRecommended Applications
STJ112137Anti-COX4I1 AntibodyMouseMonoclonalWB,IHC,FC,IP
STJ23207Anti-COX4I1 AntibodyRabbitPolyclonalWB,IHC,IF,IP,FC
STJ28647Anti-COX4I1 AntibodyRabbitPolyclonalWB,IHC,IF
STJ71237Anti-COX4I1 AntibodyGoatPolyclonalELISA,WB,IHC
STJ73178Anti-COX4I1 Antibody (Biotin)GoatPolyclonalELISA,WB,IHC

How does the Antibody Validation Project work?

In order to help our customers with their choice of antibody with low risk, we offer one of the largest ranges of primary antibodies with trial size options available.

The Antibody Validation Project works like this.
1. Order your trial size antibody online.
2. Explore its suitability.
3. Return your results by posting them on the product page.
4. Receive a sample refund.

Find out more here.