Trial size BAX antibodies available in the Antibody Validation Project

Posted by M.Popov on 12th Nov 2020

Trial size BAX antibodies available in the Antibody Validation Project

Trial size BAX antibodies available in the Antibody Validation Project

Introduction:

The BCL2 associated X, apoptosis regulator gene encodes a protein which functions as an apoptotic regulator and interacts with the VDAC. Apart from serving a major function, mutations of it can lead to cancer and several types of leukemia. We provide a number of trial sized antibodies, which are suitable for BAX research purposes, and to help you make the right decision and find the best suited antibody for you, please find the answers to some of the key topics regarding BAX that we have provided in the links below.

What is BAX?

The protein encoded by this gene belongs to the BCL2 protein family, which form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The BAX protein forms a heterodimer with BCL2, and functions as an apoptotic activator, also it is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.

Where is BAX found?

This protein is expressed mainly in the mitochondrion and nucleus, but smaller amounts can be found in the other cell structures. In the human body, it is present in the majority of the tissues.

What role does BAX play in disease?

BAX mutations have been associated with various human cancers, T-cell acute lymphoblasic leukemia and chronic lymphocytic leukemia. In lung cancer, BAX is translocated to the nucleus, enhancing the tumour growth and suppressing the BAX expression levels leads to negative cancer outcome.

BAX antibodies in the Antibody Validation project

St John's Laboratory offers a variety of trial size primary antibodies which target BAX, which are available to try through the Antibody Validation Project. Below we highlight those which have already been reviewed, as well as others which are available to try.

Customer reviewed BAX antibodies

ModelNameHostClonalityRatingApplication Tested
STJ91824Anti-Bax antibodyRabbitPolyclonal4WB

Other BAX antibodies available in the Antibody Validation Project

ModelNameHostClonalityRecommended Applications
STJ140113Anti-BAX antibodyGoatPolyclonalWB,IF
STJ91241Anti-Phospho-Bax (S184) antibodyRabbitPolyclonalIHC,ELISA
STJ91329Anti-Phospho-Bax (T167) antibodyRabbitPolyclonalIF,ELISA
STJ91820Anti-Bax antibodyRabbitPolyclonalIHC,IF,ELISA
STJ91821Anti-Bax antibodyRabbitPolyclonalWB,IHC,IF,ELISA
STJ91822Anti-Bax antibodyRabbitPolyclonalIHC,ELISA
STJ91825Anti-Bax antibodyRabbitPolyclonalIHC,ELISA
STJ97725Anti-Bax antibodyMouseMonoclonalWB,IHC
STJ97729Anti-Bax antibodyMouseMonoclonalWB,IHC
STJ99209Anti-Bax antibodyMouseMonoclonalWB,ELISA
ModelNameHostClonalityRecommended Applications
STJ113474Anti-BAX AntibodyRabbitPolyclonalWB,IHC,IF,IP,FC
STJ113834Anti-BAX AntibodyRabbitPolyclonalWB,IHC,IF
STJ113911Anti-BAX AntibodyRabbitPolyclonalWB,IHC,IF
STJ118081Anti-BAX AntibodyRabbitPolyclonalWB,IHC
STJ118092Anti-BAX AntibodyRabbitPolyclonalWB,IF
STJ22761Anti-BAX AntibodyRabbitPolyclonalWB,IHC
STJ29763Anti-BAX AntibodyRabbitPolyclonalWB,IHC
STJ29877Anti-BAX AntibodyMouseMonoclonalWB

How does the Antibody Validation Project work?

In order to help our customers with their choice of antibody with low risk, we offer one of the largest ranges of primary antibodies with trial size options available.

The Antibody Validation Project works like this.
1. Order your trial size antibody online.
2. Explore its suitability.
3. Return your results by posting them on the product page.
4. Receive a sample refund.

Find out more here.