Posted by M.Popov on 12th Nov 2020
Trial size BAK1 antibodies available in the Antibody Validation Project
Trial size BAK1 antibodies available in the Antibody Validation Project
Introduction:
BCL2 antagonist/killer 1 is a gene which encodes a protein belonging to the BCL2 family responsible for many cell activities. It is a major protein in apoptotic cell death and mutations can cause serious cancer and neurological conditions. It can be used as a prognostic marker in unfavourable renal, endometrial, liver and lung cancer. We provide a number of trial sized antibodies, which are suitable for BAK1 research purposes, and to help you make the right decision and find the best suited antibody for you, please find the answers to some of the key topics regarding BAK1 that we have provided in the links below.
- What is BAK1?
- Where is BAK1 found?
- What role does BAK1 play in disease?
- BAK1 antibodies in the Antibody Validation project
- Customer reviewed BAK1 antibodies
- Other BAK1 antibodies available in the Antibody Validation Project
- Popular BAK1 antibodies not currently in the Antibody Validation Project
- How does the Antibody Validation Project work?
What is BAK1?
The protein encoded by the BAK1 gene belongs to the BCL2 protein family, which form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosisand also interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.
Where is BAK1 found?
Inside the cell BAK1 can be primarily found in the mitochondrion and cytosol, but smaller amounts can be localised in other major cell structures. It has general cytoplasmic expression with a distinct granular pattern and can be found throughout all tissues.
What role does BAK1 play in disease?
Being a major factor in apoptotic cell death, BAK1 is regulated by other proteins to ensure that only the right cells die. Several mutations of this protein lead to lymphoma, leukemia, gastric and colorectal cancer. Apart from that, patients suffering from melanoma and have higher BAK1 levels showed higher survival rates that those who had lower levels.
BAK1 antibodies in the Antibody Validation project
St John's Laboratory offers a variety of trial size primary antibodies which target BAK1, which are available to try through the Antibody Validation Project. Below we highlight those which have already been reviewed, as well as others which are available to try.
Customer reviewed BAK1 antibodies
Currently we do not have any customer reviewed BAK1 antibodies.
Other BAK1 antibodies available in the Antibody Validation Project
| Model | Name | Host | Clonality | Recommended Applications |
|---|---|---|---|---|
| STJ91814 | Anti-Bak antibody | Rabbit | Polyclonal | ELISA,IF,IHC,WB |
Popular BAK1 antibodies not currently in the Antibody Validation Project
| Model | Name | Host | Clonality | Recommended Applications |
|---|---|---|---|---|
| STJ110972 | Anti-BAK1 Antibody | Rabbit | Polyclonal | WB,IHC |
| STJ112652 | Anti-BAK1 Antibody | Rabbit | Monoclonal | WB,IHC,IF,IP |
| STJ114891 | Anti-BAK1 Antibody | Rabbit | Polyclonal | WB,IHC |
| STJ115246 | Anti-Bak1 Antibody | Rabbit | Polyclonal | WB,IHC |
| STJ22759 | Anti-Bak1 Antibody | Rabbit | Polyclonal | WB,IF |
How does the Antibody Validation Project work?
In order to help our customers with their choice of antibody with low risk, we offer one of the largest ranges of primary antibodies with trial size options available.
The Antibody Validation Project works like this.
1. Order your trial size antibody online.
2. Explore its suitability.
3. Return your results by posting them on the product page.
4. Receive a sample refund.
Find out more here.