Posted by M.Popov on 12th Nov 2020
Trial size ARNT2 antibodies available in the Antibody Validation Project
Trial size ARNT2 antibodies available in the Antibody Validation Project
Introduction:
Aryl hydrocarbon receptor nuclear translocator 2(ARNT2) is a gene encoding a protein, mainly found in the central nervous system, acting as a partner for several sensory proteins and also complexes with the hypoxia-inducible factor 1alpha. Mutations have been reported to cause several autosomal diseases and a number of mental disorders, apart from mutations being present in human cancers. We provide a number of trial sized antibodies, which are suitable for ARNT2 research purposes, and to help you make the right decision and find the best suited antibody for you, please find the answers to some of the key topics regarding ARNT2 that we have provided in the links below.
- What is ARNT2?
- Where is ARNT2 found?
- What role does ARNT2 play in disease?
- ARNT2 antibodies in the Antibody Validation project
- Customer reviewed ARNT2 antibodies
- Other ARNT2 antibodies available in the Antibody Validation Project
- Popular ARNT2 antibodies not currently in the Antibody Validation Project
- How does the Antibody Validation Project work?
What is ARNT2?
This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli, amd under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes.
Where is ARNT2 found?
On intracellular level, the protein can be found in the nucleoplasm. The expression in the human body is very tissue specific, and this protein can be found mainly in the brain and the spinal cord. Inside the brain, it is evenly distributed and can be located in all regions.
What role does ARNT2 play in disease?
A homozygotus mutation in the ARNT2 gene is known to cause the Webb-Dattani syndrome, characterised by delayed development, pituitary and hypothalamic insufficiency, hormonal deficiencies and seizures soon after birth. The main reason for this condition is hypoplastic development of several brain regions. Apart from that, mutations have been reported in other autosomal or mental diseases and several types of human cancers.
ARNT2 antibodies in the Antibody Validation project
St John's Laboratory offers a variety of trial size primary antibodies which target ARNT2, which are available to try through the Antibody Validation Project. Below we highlight those which have already been reviewed, as well as others which are available to try.
Customer reviewed ARNT2 antibodies
| Model | Name | Host | Clonality | Rating | Application Tested |
|---|---|---|---|---|---|
| STJ91699 | Anti-Arnt 2 antibody | Rabbit | Polyclonal | 4 | IHC |
Other ARNT2 antibodies available in the Antibody Validation Project
Currently we do not have any ARNT2 antibodies in the AVP.
Popular ARNT2 antibodies not currently in the Antibody Validation Project
| Model | Name | Host | Clonality | Recommended Applications | ||
|---|---|---|---|---|---|---|
| STJ110363 | Anti-ARNT2 Antibody | Rabbit | Polyclonal | WB,IHC |
How does the Antibody Validation Project work?
In order to help our customers with their choice of antibody with low risk, we offer one of the largest ranges of primary antibodies with trial size options available.
The Antibody Validation Project works like this.
1. Order your trial size antibody online.
2. Explore its suitability.
3. Return your results by posting them on the product page.
4. Receive a sample refund.
Find out more here.