| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
ASXL1 Blocking Peptide for STJ506146 is synthetically produced from the 1120-1180 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Asxl1 |
| Gene ID: |
228790 |
| Uniprot ID: |
ASXL1_MOUSE |
| Immunogen Region: |
1120-1180 |
| Specificity: |
This blocking peptide is recommended for use in combination with ASXL1 antibody, STJ506146 |
| Immunogen: |
Synthetic peptide taken within amino acid region 1120-1180 on mouse Putative Polycomb group protein ASXL1. |
| Post Translational Modifications | Ubiquitinated by TRIP12, leading to its subsequent degradation following binding N(6)-methyladenosine methylated DNA (m6A). |
| Function | Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). Acts as a coactivator of RARA and RXRA through association with NCOA1. Acts as a corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Acts as a sensor of N(6)-methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its ubiquitination and degradation by TRIP12, thereby inactivating the PR-DUB complex and regulating Polycomb silencing. |
| Peptide Name | Polycomb Group Protein Asxl1Additional Sex Combs-Like Protein 1 |
| Database Links | Reactome: R-MMU-5689603 |
| Cellular Localisation | Nucleus |
| Alternative Peptide Names | Polycomb Group Protein Asxl1 proteinAdditional Sex Combs-Like Protein 1 proteinAsxl1 proteinKiaa0978 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
