| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:3000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ZNF281 |
| Gene ID: | 23528 |
| Uniprot ID: | ZN281_HUMAN |
| Immunogen Region: | 676-895 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 676-895 of human ZNF281 (NP_036614.1). |
| Immunogen Sequence: | FEKSTNASFTLGHGFQFVSL SSPLHNHTLFPEKQIYTTSP LECGFGQSVTSVLPSSLPKP PFGMLFGSQPGLYLSALDAT HQQLTPSQELDDLIDSQKNL ETSSAFQSSSQKLTSQKEQK NLESSTGFQIPSQELASQID PQKDIEPRTTYQIENFAQAF GSQFKSGSRVPMTFITNSNG EVDHRVRTSVSDFSGYTNMM SDVSEPCSTRVKTPTSQSYR |
| Function | Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs. Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes. |
| Protein Name | Zinc Finger Protein 281Gc-Box-Binding Zinc Finger Protein 1Transcription Factor Zbp-99Zinc Finger Dna-Binding Protein 99 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Zinc Finger Protein 281 antibodyAnti-Gc-Box-Binding Zinc Finger Protein 1 antibodyAnti-Transcription Factor Zbp-99 antibodyAnti-Zinc Finger Dna-Binding Protein 99 antibodyAnti-ZNF281 antibodyAnti-GZP1 antibodyAnti-ZBP99 antibody |
Information sourced from Uniprot.org