| Tissue Specificity | Overexpressed in ovarian cancer tissues compared to normal ovarian tissues. Isoform 1 and isoform 2 are expressed in squamous epithelium tissues. Isoform 2 is overexpressed in squamous cervical cancer (at protein level). Expressed in blood cells. Isoform 1 is expressed in pancreas, lung, skeletal muscle, heart, placenta, liver, kidney and brain. Isoform 2 expressed in chronic lymphocytic leukemia (CLL) and several tumor cell lines. Isoform 3 is expressed in several tumor cells. Isoform 5 is expressed in fetal liver and several tumor cells. Isoform 6 is weakly expressed in brain, lung amd small intestin and in several tumor cells. Isoform 7 is expressed in fetal liver and several tumor cells. |
| Function | Isoform 1: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression. Isoform 2: Contributes to cervical carcinogenesis in part through the TNF-alpha-induced NF-kappa-B signaling pathway by interacting with the I-kappa-B-kinase (IKK) core complex. |
| Protein Name | Zinc Finger Protein 268Zinc Finger Protein Hzf3 |
| Database Links | Reactome: R-HSA-212436 |
| Cellular Localisation | Isoform 1: NucleusIsoform 2: NucleusCytoplasm |
| Alternative Antibody Names | Anti-Zinc Finger Protein 268 antibodyAnti-Zinc Finger Protein Hzf3 antibodyAnti-ZNF268 antibody |
Information sourced from Uniprot.org
