| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ZDHHC6 (279-413) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ZDHHC6 |
| Gene ID: |
64429 |
| Uniprot ID: |
ZDHC6_HUMAN |
| Immunogen Region: |
279-413 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 279-413 of human ZDHHC6 (NP_071939.1). |
| Immunogen Sequence: |
SGVPEGDGLEWPVREGCHQY SLTIEQLKQKADKRVRSVRY KVIEDYSGACCPLNKGIKTF FTSPCTEEPRIQLQKGEFIL ATRGLRYWLYGDKILDDSFI EGVSRIRGWFPRKCVEKCPC DAETDQAPEGEKKNR |
| Post Translational Modifications | Palmitoylated at 3 different sites by ZDHHC16. The combination of the different palmitoylation events strongly affects the quaternary assembly of ZDHHC6, its localization, stability and function. Palmitoylation at Cys-328 accelerates the turnover of ZDHHC6. Depalmitoylated by LYPLA2. |
| Function | Endoplasmic reticulum palmitoyl acyltransferase that mediates palmitoylation of proteins such as AMFR, CALX, ITPR1 and TFRC. Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins. Mediates palmitoylation of AMFR, promoting AMFR distribution to the peripheral endoplasmic reticulum. Together with SELENOK, palmitoylates ITPR1 in immune cells, leading to regulate ITPR1 stability and function. Stearoyltransferase that mediates stearoylation of TFRC to inhibit TFRC-mediated activation of the JNK pathway and mitochondrial fragmentation. |
| Protein Name | Palmitoyltransferase Zdhhc6Stearoyltransferase Zdhhc6Transmembrane Protein H4Zinc Finger Dhhc Domain-Containing Protein 6Dhhc-6Zinc Finger Protein 376 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinWhen Not PalmitoylatedAccumulates To Dot-Like Structures In The Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Palmitoyltransferase Zdhhc6 antibodyAnti-Stearoyltransferase Zdhhc6 antibodyAnti-Transmembrane Protein H4 antibodyAnti-Zinc Finger Dhhc Domain-Containing Protein 6 antibodyAnti-Dhhc-6 antibodyAnti-Zinc Finger Protein 376 antibodyAnti-ZDHHC6 antibodyAnti-ZNF376 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
