| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ZDHHC18 |
| Gene ID: | 84243 |
| Uniprot ID: | ZDH18_HUMAN |
| Immunogen Region: | 301-388 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 301-388 of human ZDHHC18 (NP_115659.1). |
| Immunogen Sequence: | YLVASNLTTNEDIKGSWSSK RGGEASVNPYSHKSIITNCC AVLCGPLPPSLIDRRGFVQS DTVLPSPIRSDEPACRAKPD ASMVGGHP |
| Tissue Specificity | Widely expressed. |
| Function | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as CGAS, HRAS and LCK. Acts as a negative regulator of the cGAS-STING pathway be mediating palmitoylation and inactivation of CGAS. May also have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling. |
| Protein Name | Palmitoyltransferase Zdhhc18Dhhc Domain-Containing Cysteine-Rich Protein 18Dhhc-18Zinc Finger Dhhc Domain-Containing Protein 18 |
| Cellular Localisation | Golgi Apparatus MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Palmitoyltransferase Zdhhc18 antibodyAnti-Dhhc Domain-Containing Cysteine-Rich Protein 18 antibodyAnti-Dhhc-18 antibodyAnti-Zinc Finger Dhhc Domain-Containing Protein 18 antibodyAnti-ZDHHC18 antibody |
Information sourced from Uniprot.org