| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-IFIT1 (301-388) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IFIT1 |
| Gene ID: |
3434 |
| Uniprot ID: |
IFIT1_HUMAN |
| Immunogen Region: |
301-388 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 301-388 of human IFIT1 (NP_001539.3). |
| Immunogen Sequence: |
QIKEATKGQPRGQNREKLDK MIRSAIFHFESAVEKKPTFE VAHLDLARMYIEAGNHRKAE ENFQKLLCMKPVVEETMQDI HFHYGRFQ |
| Post Translational Modifications | Phosphorylated. ISGylated. |
| Function | Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses. |
| Protein Name | Interferon-Induced Protein With Tetratricopeptide Repeats 1Ifit-1Interferon-Induced 56 Kda ProteinIfi-56kP56 |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-909733 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Interferon-Induced Protein With Tetratricopeptide Repeats 1 antibodyAnti-Ifit-1 antibodyAnti-Interferon-Induced 56 Kda Protein antibodyAnti-Ifi-56k antibodyAnti-P56 antibodyAnti-IFIT1 antibodyAnti-G10P1 antibodyAnti-IFI56 antibodyAnti-IFNAI1 antibodyAnti-ISG56 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
