| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-XRN2 (1-950) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
XRN2 |
| Gene ID: |
22803 |
| Uniprot ID: |
XRN2_HUMAN |
| Immunogen Region: |
1-950 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-950 of human XRN2 (Q9H0D6). |
| Immunogen Sequence: |
MGVPAFFRWLSRKYPSIIVN CVEEKPKECNGVKIPVDASK PNPNDVEFDNLYLDMNGIIH PCTHPEDKPAPKNEDEMMVA IFEYIDRLFSIVRPRRLLYM AIDGVAPRAKMNQQRSRRFR ASKEGMEAAVEKQRVREEIL AKGGFLPPEEIKERFDSNCI TPGTEFMDNLAKCLRYYIAD RLNNDPGWKNLTVILSDASA PGEGEHKIMDYIRRQRAQPN HDPNTHHCLCGADADLIML |
| Tissue Specificity | Expressed in the spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Isoform 2 is expressed predominantly in peripheral blood leukocytes. |
| Function | Possesses 5'->3' exoribonuclease activity. May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites. |
| Protein Name | 5'-3' Exoribonuclease 2Dhm1-Like ProteinDhp Protein |
| Database Links | Reactome: R-HSA-390471Reactome: R-HSA-6791226 |
| Cellular Localisation | NucleusNucleolus |
| Alternative Antibody Names | Anti-5'-3' Exoribonuclease 2 antibodyAnti-Dhm1-Like Protein antibodyAnti-Dhp Protein antibodyAnti-XRN2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
