| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-WISP1 (158-367) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CCN4 |
| Gene ID: |
8840 |
| Uniprot ID: |
CCN4_HUMAN |
| Immunogen Region: |
158-367 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 158-367 of human WISP1 (NP_003873.1). |
| Immunogen Sequence: |
LRVRPPRLWCPHPRRVSIPG HCCEQWVCEDDAKRPRKTAP RDTGAFDAVGEVEAWHRNCI AYTSPWSPCSTSCGLGVSTR ISNVNAQCWPEQESRLCNLR PCDVDIHTLIKAGKKCLAVY QPEASMNFTLAGCISTRSYQ PKYCGVCMDNRCCIPYKSKT IDVSFQCPDGLGFSRQVLWI NACFCNLSCRNPNDIFADLE SYPDFSEIAN |
| Tissue Specificity | Expressed in heart, kidney, lung, pancreas, placenta, ovary, small intestine and spleen. Isoform 2 is expressed predominantly in scirrhous gastric carcinoma and, weakly in placenta. Overexpression is associated with several cancers including breast cancer and colon tumors. Isoform 2 is overexpressed in scirrhous gastric carcinoma. |
| Function | Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan. |
| Protein Name | Ccn Family Member 4Wnt1-Inducible-Signaling Pathway Protein 1Wisp-1Wnt-1-Induced Secreted Protein |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Ccn Family Member 4 antibodyAnti-Wnt1-Inducible-Signaling Pathway Protein 1 antibodyAnti-Wisp-1 antibodyAnti-Wnt-1-Induced Secreted Protein antibodyAnti-CCN4 antibodyAnti-WISP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
