| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | WBP2 |
| Gene ID: | 23558 |
| Uniprot ID: | WBP2_HUMAN |
| Immunogen Region: | 15-140 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 15-140 of human WBP2 (NP_036610.2). |
| Immunogen Sequence: | VNNTESILMSYDHVELTFND MKNVPEAFKGTKKGTVYLTP YRVIFLSKGKDAMQSFMMPF YLMKDCEIKQPVFGANYIKG TVKAEAGGGWEGSASYKLTF TAGGAIEFGQRMLQVASQAS RGEVPS |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Phosphorylated in repsonse to EGF as well as estrogen and progesterone hormones. Tyr-192 and Tyr-231 are phosphorylated by YES and SRC inducing nuclear translocation. |
| Function | Acts as a transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation. In presence of estrogen, binds to ESR1-responsive promoters. Synergizes with YAP1 to enhance PGR activity. Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR. |
| Protein Name | Ww Domain-Binding Protein 2Wbp-2 |
| Cellular Localisation | CytoplasmNucleusTranslocates From Cytoplasm To Nucleus When Phosphorylated |
| Alternative Antibody Names | Anti-Ww Domain-Binding Protein 2 antibodyAnti-Wbp-2 antibodyAnti-WBP2 antibody |
Information sourced from Uniprot.org