| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-WBP2 (15-140) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
WBP2 |
| Gene ID: |
23558 |
| Uniprot ID: |
WBP2_HUMAN |
| Immunogen Region: |
15-140 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 15-140 of human WBP2 (NP_036610.2). |
| Immunogen Sequence: |
VNNTESILMSYDHVELTFND MKNVPEAFKGTKKGTVYLTP YRVIFLSKGKDAMQSFMMPF YLMKDCEIKQPVFGANYIKG TVKAEAGGGWEGSASYKLTF TAGGAIEFGQRMLQVASQAS RGEVPS |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Phosphorylated in repsonse to EGF as well as estrogen and progesterone hormones. Tyr-192 and Tyr-231 are phosphorylated by YES and SRC inducing nuclear translocation. |
| Function | Acts as transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation. In presence of estrogen, binds to ESR1-responsive promoters. Required for YAP1 coactivation function on PGR activity. Synergizes with WBP2 in enhancing PGR activity. Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR. |
| Protein Name | Ww Domain-Binding Protein 2Wbp-2 |
| Cellular Localisation | CytoplasmNucleusTranslocates From Cytoplasm To Nucleus When Phosphorylated |
| Alternative Antibody Names | Anti-Ww Domain-Binding Protein 2 antibodyAnti-Wbp-2 antibodyAnti-WBP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
