| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-B7-H4/VTCN1 (100-260) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
VTCN1 |
| Gene ID: |
79679 |
| Uniprot ID: |
VTCN1_HUMAN |
| Immunogen Region: |
100-260 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 100-260 of human B7-H4/VTCN1 (NP_078902.2). |
| Immunogen Sequence: |
RTAVFADQVIVGNASLRLKN VQLTDAGTYKCYIITSKGKG NANLEYKTGAFSMPEVNVDY NASSETLRCEAPRWFPQPTV VWASQVDQGANFSEVSNTSF ELNSENVTMKVVSVLYNVTI NNTYSCMIENDIAKATGDIK VTESEIKRRSHLQLLNSKAS L |
| Tissue Specificity | Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis. |
| Post Translational Modifications | N-glycosylated. |
| Function | Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. |
| Protein Name | V-Set Domain-Containing T-Cell Activation Inhibitor 1B7 Homolog 4B7-H4B7h.5Immune Costimulatory Protein B7-H4Protein B7s1T-Cell Costimulatory Molecule B7x |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinExpressed At The Cell SurfaceA Soluble Form Has Also Been Detected |
| Alternative Antibody Names | Anti-V-Set Domain-Containing T-Cell Activation Inhibitor 1 antibodyAnti-B7 Homolog 4 antibodyAnti-B7-H4 antibodyAnti-B7h.5 antibodyAnti-Immune Costimulatory Protein B7-H4 antibodyAnti-Protein B7s1 antibodyAnti-T-Cell Costimulatory Molecule B7x antibodyAnti-VTCN1 antibodyAnti-B7H4 antibodyAnti-UNQ659 antibodyAnti-PRO1291 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
