| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-VPS36 (70-220) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
VPS36 |
| Gene ID: |
51028 |
| Uniprot ID: |
VPS36_HUMAN |
| Immunogen Region: |
70-220 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 70-220 of human VPS36 (NP_057159.2). |
| Immunogen Sequence: |
EEQAAGIGKSAKIVVHLHPA PPNKEPGPFQSSKNSYIKLS FKEHGQIEFYRRLSEEMTQR RWENMPVSQSLQTNRGPQPG RIRAVGIVGIERKLEEKRKE TDKNISEAFEDLSKLMIKAK EMVELSKSIANKIKDKQGDI TEDETIRFKSY |
| Function | Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3. |
| Protein Name | Vacuolar Protein-Sorting-Associated Protein 36Ell-Associated Protein Of 45 KdaEscrt-Ii Complex Subunit Vps36 |
| Database Links | Reactome: R-HSA-917729Reactome: R-HSA-9610379 |
| Cellular Localisation | CytoplasmEndosomeLate EndosomeMembraneNucleusColocalizes With Ubiquitinated Proteins On Late EndosomesRecruited To The Endosome Membrane To Participate In Vesicle Formation |
| Alternative Antibody Names | Anti-Vacuolar Protein-Sorting-Associated Protein 36 antibodyAnti-Ell-Associated Protein Of 45 Kda antibodyAnti-Escrt-Ii Complex Subunit Vps36 antibodyAnti-VPS36 antibodyAnti-C13orf9 antibodyAnti-EAP45 antibodyAnti-CGI-145 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
