| Function | Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked ubiquitin chains. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 19Deubiquitinating Enzyme 19Ubiquitin Thioesterase 19Ubiquitin-Specific-Processing Protease 19Zinc Finger Mynd Domain-Containing Protein 9 |
| Database Links | Reactome: R-HSA-5689880 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase 19 antibodyAnti-Deubiquitinating Enzyme 19 antibodyAnti-Ubiquitin Thioesterase 19 antibodyAnti-Ubiquitin-Specific-Processing Protease 19 antibodyAnti-Zinc Finger Mynd Domain-Containing Protein 9 antibodyAnti-USP19 antibodyAnti-KIAA0891 antibodyAnti-ZMYND9 antibody |
Information sourced from Uniprot.org
