| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ULK2 (390-490) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ULK2 |
| Gene ID: |
9706 |
| Uniprot ID: |
ULK2_HUMAN |
| Immunogen Region: |
390-490 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 390-490 of human ULK2 (NP_001136082.1). |
| Immunogen Sequence: |
PTVSPHSETAPIPVPTQIRN YQRIEQNLTSTASSGTNVHG SPRSAVVRRSNTSPMGFLRP GSCSPVPADTAQTVGRRLST GSSRPYSPSPLVGTIPEQFS Q |
| Post Translational Modifications | Autophosphorylated. In response to nutrient limitation, probably phosphorylated and activated by AMPK, leading to activate autophagy. |
| Function | Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR.however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons. |
| Protein Name | Serine/Threonine-Protein Kinase Ulk2Unc-51-Like Kinase 2 |
| Cellular Localisation | Cytoplasmic Vesicle MembranePeripheral Membrane ProteinLocalizes To Pre-Autophagosomal Membrane |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Ulk2 antibodyAnti-Unc-51-Like Kinase 2 antibodyAnti-ULK2 antibodyAnti-KIAA0623 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
