| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | UAP1 |
| Gene ID: | 6675 |
| Uniprot ID: | UAP1_HUMAN |
| Immunogen Region: | 1-290 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human UAP1 (NP_003106.3). |
| Immunogen Sequence: | MNINDLKLTLSKAGQEHLLR FWNELEEAQQVELYAELQAM NFEELNFFFQKAIEGFNQSS HQKNVDARMEPVPREVLGSA TRDQDQLQAWESEGLFQISQ NKVAVLLLAGGQGTRLGVAY PKGMYDVGLPSRKTLFQIQA ERILKLQQVAEKYYGNKCII PWYIMTSGRTMESTKEFFTK HKYFGLKKENVIFFQQGMLP AMSFDGKIILEEKNKVSMAP DGNGGLYRALAAQNIVEDM |
| Tissue Specificity | Widely expressed. Expressed at low level in placenta, muscle and liver. Isoform AGX1: Isoform AGX1 is more abundant in testis than isoform AGX2, while isoform AGX2 is more abundant than isoform AGX1 in somatic tissue. Isoform AGX2: Isoform AGX2 is more abundant than isoform AGX1 in somatic tissue. |
| Function | Catalyzes the last step in biosynthesis of uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) by converting UTP and glucosamine 1-phosphate (GlcNAc-1-P) to the sugar nucleotide. Also converts UTP and galactosamine 1-phosphate (GalNAc-1-P) into uridine diphosphate-N-acetylgalactosamine (UDP-GalNAc). In addition to its role in metabolism, acts as a regulator of innate immunity in response to virus infection by mediating pyrophosphorylation of IRF3: catalyzes pyrophosphorylation of IRF3 phosphorylated at 'Ser-386' by TBK1, promoting IRF3 dimerization and activation, leading to type I interferon responses. Isoform AGX1: Isoform AGX1 has 2 to 3 times higher activity towards galactosamine 1-phosphate (GalNAc-1-P). Isoform AGX1: Isoform AGX2 has 8 times more activity towards glucosamine 1-phosphate (GlcNAc-1-P). |
| Protein Name | Udp-N-Acetylhexosamine Pyrophosphorylase Antigen X Agx Protein-Pyrophosphorylation Enzyme Sperm-Associated Antigen 2 Udp-N-Acetylgalactosamine Pyrophosphorylase Udp-N-Acetylglucosamine Pyrophosphorylase |
| Database Links | Reactome: R-HSA-446210 |
| Cellular Localisation | Cytoplasm Cytosol In Spermatozoa Localized To The Principal Piece Of The Tail The Neck Region Of The Head And To A Lesser Extent The Midpiece Of The Tail |
| Alternative Antibody Names | Anti-Udp-N-Acetylhexosamine Pyrophosphorylase antibody Anti-Antigen X antibody Anti-Agx antibody Anti-Protein-Pyrophosphorylation Enzyme antibody Anti-Sperm-Associated Antigen 2 antibody Anti-Udp-N-Acetylgalactosamine Pyrophosphorylase antibody Anti-Udp-N-Acetylglucosamine Pyrophosphorylase antibody Anti-UAP1 antibody Anti-SPAG2 antibody |
Information sourced from Uniprot.org
