• Immunofluorescence analysis of human liver cancer using TTR Polyclonal Antibody (STJ25987) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

Anti-TTR antibody (1-147) (STJ25987)

SKU:
STJ25987

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Host: Rabbit
Applications: IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-TTR (1-147) is suitable for use in Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TTR
Gene ID: 7276
Uniprot ID: TTHY_HUMAN
Immunogen Region: 1-147
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-147 of human TTR (P02766).
Immunogen Sequence: MASHRLLLLCLAGLVFVSEA GPTGTGESKCPLMVKVLDAV RGSPAINVAVHVFRKAADDT WEPFASGKTSESGELHGLTT EEEFVEGIYKVEIDTKSYWK ALGISPFHEHAEVVFTANDS GPRRYTIAALLSPYSYSTTA VVTNPKE
Tissue Specificity Detected in serum and cerebrospinal fluid (at protein level). Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver.
Post Translational Modifications Not glycosylated under normal conditions. Following unfolding, caused for example by variant AMYL-TTR 'Gly-38', the cryptic Asn-118 site is exposed and glycosylated by STT3B-containing OST complex, leading to its degradation by the ER-associated degradation (ERAD) pathway. Sulfonation of the reactive cysteine Cys-30 enhances the stability of the native conformation of TTR, avoiding misassembly of the protein leading to amyloid formation.
Function Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
Protein Name Transthyretin
Attr
Prealbumin
Tbpa
Database Links Reactome: R-HSA-2453864
Reactome: R-HSA-2453902
Reactome: R-HSA-3000171
Reactome: R-HSA-6798695
Reactome: R-HSA-975634
Reactome: R-HSA-977225
Cellular Localisation Secreted
Cytoplasm
Alternative Antibody Names Anti-Transthyretin antibody
Anti-Attr antibody
Anti-Prealbumin antibody
Anti-Tbpa antibody
Anti-TTR antibody
Anti-PALB antibody

Information sourced from Uniprot.org

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