| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TSPAN17 |
| Gene ID: | 26262 |
| Uniprot ID: | TSN17_HUMAN |
| Immunogen Region: | 116-234 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 116-234 of human TSPAN17 (NP_001006617.2). |
| Immunogen Sequence: | VFKDWIRDQLNLFINNNVKA YRDDIDLQNLIDFAQEYWSC CGARGPNDWNLNIYFNCTDL NPSRERCGVPFSCCVRDPAE DVLNTQCGYDVRLKLELEQQ GFIHTKGCVGQFEKWLQDN |
| Function | Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates. Seems to regulate VE-cadherin expression in endothelial cells probably through interaction with ADAM10, promoting leukocyte transmigration. |
| Protein Name | Tetraspanin-17Tspan-17F-Box Only Protein 23Tetraspan Protein Sb134Transmembrane 4 Superfamily Member 17 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Tetraspanin-17 antibodyAnti-Tspan-17 antibodyAnti-F-Box Only Protein 23 antibodyAnti-Tetraspan Protein Sb134 antibodyAnti-Transmembrane 4 Superfamily Member 17 antibodyAnti-TSPAN17 antibodyAnti-FBXO23 antibodyAnti-TM4SF17 antibody |
Information sourced from Uniprot.org