| Tissue Specificity | Strongly expressed in fetal brain, liver and kidney, and in adult prostate, testis, ovary, colon and peripheral blood leukocytes. Also expressed in a large proportion of Wilms' tumors and rhabdomyosarcomas. In monochromosomal cell lines shows exclusive paternal expression. |
| Post Translational Modifications | Ser-129 phosphorylation by PKC, is essential for activating TRPM5 via the G(q) pathway. |
| Function | Monovalent cation-selective ion channel activated by intracellular Ca(2+) in a voltage- and temperature-dependent manner. Mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increase in intracellular Ca(2+), but is impermeable to it. The activation mechanism of TRPM5 involves a multistep process. TRPM5 activation involves ligand binding (i.e., tastant molecule, glucose stimulation) to Gq/G-protein coupled receptors (GPCR) and leads to the breakdown of phosphatidylinositol bisphosphate (PIP2) into diacylglycerol (DAG) and inositol trisphosphate (IP3), IP3 binds to its receptors in the endoplasmic reticulum and cause calcium release. Simultaneously with the intracellular Ca(2+) release, DAG activates the protein kinase C (PKC), which phosphorylates the TRPM5 channel. This phosphorylation combined with the bound Ca(2+), leads to a robust inward current allowing the entry of sodium ions (Na+) into the cell. This ion influx depolarizes the cell membrane, generating action potentials that propagate TRPM5 signals. Is a key player in sensing sweet, umami and bitter stimuli. Involved in insulin secretion by pancreatic beta cells. |
| Protein Name | Transient Receptor Potential Cation Channel Subfamily M Member 5Long Transient Receptor Potential Channel 5Ltrpc-5Ltrpc5Mlsn1- And Trp-Related Gene 1 Protein |
| Database Links | Reactome: R-HSA-3295583Reactome: R-HSA-9717207 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Transient Receptor Potential Cation Channel Subfamily M Member 5 antibodyAnti-Long Transient Receptor Potential Channel 5 antibodyAnti-Ltrpc-5 antibodyAnti-Ltrpc5 antibodyAnti-Mlsn1- And Trp-Related Gene 1 Protein antibodyAnti-TRPM5 antibodyAnti-LTRPC5 antibodyAnti-MTR1 antibody |
Information sourced from Uniprot.org
