| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TRPM5 (1026-1165) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TRPM5 |
| Gene ID: |
29850 |
| Uniprot ID: |
TRPM5_HUMAN |
| Immunogen Region: |
1026-1165 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1026-1165 of human TRPM5 (NP_055370.1). |
| Immunogen Sequence: |
RVFKKEAEHKREHLERDLPD PLDQKVVTWETVQKENFLSK MEKRRRDSEGEVLRKTAHRV DFIAKYLGGLREQEKRIKCL ESQINYCSVLVSSVADVLAQ GGGPRSSQHCGEGSQLVAAD HRGGLDGWEQPGAGQPPSDT |
| Tissue Specificity | Strongly expressed in fetal brain, liver and kidney, and in adult prostate, testis, ovary, colon and peripheral blood leukocytes. Also expressed in a large proportion of Wilms' tumors and rhabdomyosarcomas. In monochromosomal cell lines shows exclusive paternal expression. |
| Function | Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals. |
| Protein Name | Transient Receptor Potential Cation Channel Subfamily M Member 5Long Transient Receptor Potential Channel 5Ltrpc-5Ltrpc5Mlsn1- And Trp-Related Gene 1 Protein |
| Database Links | Reactome: R-HSA-3295583Reactome: R-HSA-9717207 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Transient Receptor Potential Cation Channel Subfamily M Member 5 antibodyAnti-Long Transient Receptor Potential Channel 5 antibodyAnti-Ltrpc-5 antibodyAnti-Ltrpc5 antibodyAnti-Mlsn1- And Trp-Related Gene 1 Protein antibodyAnti-TRPM5 antibodyAnti-LTRPC5 antibodyAnti-MTR1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
