| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TRIM9 (1-160) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TRIM9 |
| Gene ID: |
114088 |
| Uniprot ID: |
TRIM9_HUMAN |
| Immunogen Region: |
1-160 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human TRIM9 (NP_055978.4). |
| Immunogen Sequence: |
MEEMEEELKCPVCGSFYREP IILPCSHNLCQACARNILVQ TPESESPQSHRAAGSGVSDY DYLDLDKMSLYSEADSGYGS YGGFASAPTTPCQKSPNGVR VFPPAMPPPATHLSPALAPV PRNSCITCPQCHRSLILDDR GLRGFPKNRVLEGVIDRYQQ |
| Tissue Specificity | Brain. Highly expressed in the cerebral cortex (at protein level). Severely decreased in the affected brain areas in Parkinson disease and dementia with Lewy bodies. |
| Post Translational Modifications | Auto-ubiquitinated. Poly-ubiquitinated in cultured cells, whereas it is monoubiquitinated in vitro. |
| Function | E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim9Ring Finger Protein 91Ring-Type E3 Ubiquitin Transferase Trim9Tripartite Motif-Containing Protein 9 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmCell ProjectionDendriteCytoplasmic VesicleSecretory VesicleSynaptic VesicleSynapseCytoskeletonEnriched At Synaptic Terminals Where It Exists In A Soluble Form And A Synaptic Vesicle-Associated FormAssociated With The CytoskeletonFound In Proximal Dendrites Of Pyramidal Neurons In The Cerebral Cortex And HippocampusAnd Purkinje Cells In The Cerebellum |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim9 antibodyAnti-Ring Finger Protein 91 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Trim9 antibodyAnti-Tripartite Motif-Containing Protein 9 antibodyAnti-TRIM9 antibodyAnti-KIAA0282 antibodyAnti-RNF91 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
