| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TRIM56 (300-600) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TRIM56 |
| Gene ID: |
81844 |
| Uniprot ID: |
TRI56_HUMAN |
| Immunogen Region: |
300-600 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 300-600 of human TRIM56 (NP_112223.1). |
| Immunogen Sequence: |
QVARAAAAFARRVLSLGREA EILSLEGAIAQRLRQLQGCP WAPGPAPCLLPQLELHPGLL DKNCHLLRLSFEEQQPQKDG GKDGAGTQGGEESQSRREDE PKTERQGGVQPQAGDGAQTP KEEKAQTTREEGAQTLEEDR AQTPHEDGGPQPHRGGRPNK KKKFKGRLKSISREPSPALG PNLDGSGLLPRPIFYCSFPT RMPGDKRSPRITGLCPFGPR EILVADEQNRALKRFSLNG |
| Tissue Specificity | Widely expressed (at protein level). |
| Post Translational Modifications | (Microbial infection) Preferentially ubiquitinated with 'Lys-48' and 'Lys-11'-linked ubiquitin chains by Salmonella effector SopA leading to proteasomal targeting and degradation. Autoubiquitinated. |
| Function | E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity by mediating ubiquitination of CGAS and STING1. In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets STING1 to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta. Also mediate monoubiquitination of CGAS, thereby promoting CGAS oligomerization and subsequent activation. Promotes also TNFalpha-induced NF-kappa-B signaling by mediating 'Lys-63'-linked ubiquitination TAK1, leading to enhanced interaction between TAK1 and CHUK/IKKalpha. Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES. Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus. Acts as restriction factor of Zika virus through direct interaction with the viral RNA via its C-terminal region. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim56Ring Finger Protein 109Tripartite Motif-Containing Protein 56 |
| Database Links | Reactome: R-HSA-3134975 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim56 antibodyAnti-Ring Finger Protein 109 antibodyAnti-Tripartite Motif-Containing Protein 56 antibodyAnti-TRIM56 antibodyAnti-RNF109 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
