| Host: |
Rabbit |
| Applications: |
WB/IHC/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TRIM16 (1-210) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TRIM16 |
| Gene ID: |
10626 |
| Uniprot ID: |
TRI16_HUMAN |
| Immunogen Region: |
1-210 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human TRIM16 (NP_006461.3). |
| Immunogen Sequence: |
MAELDLMAPGPLPRATAQPP APLSPDSGSPSPDSGSASPV EEEDVGSSEKLGRETEEQDS DSAEQGDPAGEGKEVLCDFC LDDTRRVKAVKSCLTCMVNY CEEHLQPHQVNIKLQSHLLT EPVKDHNWRYCPAHHSPLSA FCCPDQQCICQDCCQEHSGH TIVSLDAARRDKEAELQCTQ LDLERKLKLNENAISRLQAN QKSVLVSVSE |
| Tissue Specificity | Highest levels found in testis, ovary, small intestine, colon, placenta, heart, skeletal muscle and mammary gland. More highly expressed in the fetus than in the corresponding adult tissues. Expressed in basal keratinocytes. |
| Post Translational Modifications | Phosphorylated by ULK1. Auto-ubiquitinates via its B-Boxes. |
| Function | E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage. |
| Protein Name | Tripartite Motif-Containing Protein 16E3 Ubiquitin-Protein Ligase Trim16Estrogen-Responsive B Box Protein |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Tripartite Motif-Containing Protein 16 antibodyAnti-E3 Ubiquitin-Protein Ligase Trim16 antibodyAnti-Estrogen-Responsive B Box Protein antibodyAnti-TRIM16 antibodyAnti-EBBP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
