| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TRIM15 (1-330) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TRIM15 |
| Gene ID: |
89870 |
| Uniprot ID: |
TRI15_HUMAN |
| Immunogen Region: |
1-330 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-330 of human TRIM15 (NP_150232.2). |
| Immunogen Sequence: |
MPATPSLKVVHELPACTLCA GPLEDAVTIPCGHTFCRLCL PALSQMGAQSSGKILLCPLC QEEEQAETPMAPVPLGPLGE TYCEEHGEKIYFFCENDAEF LCVFCREGPTHQAHTVGFLD EAIQPYRDRLRSRLEALSTE RDEIEDVKCQEDQKLQVLLT QIESKKHQVETAFERLQQEL EQQRCLLLARLRELEQQIWK ERDEYITKVSEEVTRLGAQV KELEEKCQQPASELLQDVR |
| Function | E3 ubiquitin ligase that plays a role in several processes including innate antiviral immnity, cell migration and chemotaxis. Acts as a 'Lys-63'-specific ubiquitin ligase for MAPK1/ERK2 and MAPK3/ERK1, promoting their activation by facilitating their interaction with MAP2K1 and MAP2K2. Plays also a role in cell migration and chemotaxis by acting as a stable focal adhesion component upon recruitment by multi-adapter protein paxillin/PXN. Functions in the RIGI-mediated interferon induction pathway upstream or at the level of MAVS. Inhibits NF-kappa-B activation by turnover of 'Lys-63'-linked ubiquitination of MAP3K7/TAK1. Mechanistically, prevents TRIM8 cytoplasmic translocation and thus inhibits TRIM8-mediated 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 in the cytoplasm. Plays also an important regulatory effect on the activation of hepatic stellate cells (HSCs). |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim15Ring Finger Protein 93Zinc Finger Protein 178Zinc Finger Protein B7 |
| Cellular Localisation | CytoplasmNucleusCell JunctionFocal AdhesionLocalizes To Focal Adhesions During The Early Stage Of Adhesion Biogenesis |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim15 antibodyAnti-Ring Finger Protein 93 antibodyAnti-Zinc Finger Protein 178 antibodyAnti-Zinc Finger Protein B7 antibodyAnti-TRIM15 antibodyAnti-RNF93 antibodyAnti-ZNF178 antibodyAnti-ZNFB7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
