• Western blot analysis of various lysates using TRIM11 Rabbit polyclonal antibody (STJ115826) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-TRIM11 antibody (267-468) (STJ115826)

SKU:
STJ115826

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Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-TRIM11 (267-468) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TRIM11
Gene ID: 81559
Uniprot ID: TRI11_HUMAN
Immunogen Region: 267-468
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 267-468 of human TRIM11 (NP_660215.1).
Immunogen Sequence: MELRTVCRVPGLVETLRRFR GDVTLDPDTANPELILSEDR RSVQRGDLRQALPDSPERFD PGPCVLGQERFTSGRHYWEV EVGDRTSWALGVCRENVNRK EKGELSAGNGFWILVFLGSY YNSSERALAPLRDPPRRVGI FLDYEAGHLSFYSATDGSLL FIFPEIPFSGTLRPLFSPLS SSPTPMTICRPKGGSGDTLA PQ
Tissue Specificity Ubiquitous.
Post Translational Modifications Autoubiquitinated upon DNA stimulation.autoubiquitination at Lys-458 promotes interaction with SQSTM1/p62 and recruitment of AIM2 to autophagosomes.
Function E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle. Acts as an inhibitor of the AIM2 inflammasome by promoting autophagy-dependent degradation of AIM2. Mechanistically, undergoes autoubiquitination upon DNA stimulation, promoting interaction with AIM2 and SQSTM1/p62, leading to AIM2 recruitment to autophagosomes.
Protein Name E3 Ubiquitin-Protein Ligase Trim11
Protein Bia1
Ring Finger Protein 92
Tripartite Motif-Containing Protein 11
Database Links Reactome: R-HSA-983168
Cellular Localisation Cytoplasm
Nucleus
Alternative Antibody Names Anti-E3 Ubiquitin-Protein Ligase Trim11 antibody
Anti-Protein Bia1 antibody
Anti-Ring Finger Protein 92 antibody
Anti-Tripartite Motif-Containing Protein 11 antibody
Anti-TRIM11 antibody
Anti-RNF92 antibody

Information sourced from Uniprot.org

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