| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TRIM11 (267-468) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TRIM11 |
| Gene ID: |
81559 |
| Uniprot ID: |
TRI11_HUMAN |
| Immunogen Region: |
267-468 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 267-468 of human TRIM11 (NP_660215.1). |
| Immunogen Sequence: |
MELRTVCRVPGLVETLRRFR GDVTLDPDTANPELILSEDR RSVQRGDLRQALPDSPERFD PGPCVLGQERFTSGRHYWEV EVGDRTSWALGVCRENVNRK EKGELSAGNGFWILVFLGSY YNSSERALAPLRDPPRRVGI FLDYEAGHLSFYSATDGSLL FIFPEIPFSGTLRPLFSPLS SSPTPMTICRPKGGSGDTLA PQ |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Autoubiquitinated upon DNA stimulation.autoubiquitination at Lys-458 promotes interaction with SQSTM1/p62 and recruitment of AIM2 to autophagosomes. |
| Function | E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle. Acts as an inhibitor of the AIM2 inflammasome by promoting autophagy-dependent degradation of AIM2. Mechanistically, undergoes autoubiquitination upon DNA stimulation, promoting interaction with AIM2 and SQSTM1/p62, leading to AIM2 recruitment to autophagosomes. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim11Protein Bia1Ring Finger Protein 92Tripartite Motif-Containing Protein 11 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim11 antibodyAnti-Protein Bia1 antibodyAnti-Ring Finger Protein 92 antibodyAnti-Tripartite Motif-Containing Protein 11 antibodyAnti-TRIM11 antibodyAnti-RNF92 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
