| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TRABD2B |
| Gene ID: | 388630 |
| Uniprot ID: | TIKI2_HUMAN |
| Immunogen Region: | 355-490 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 355-490 of human TRABD2B (A6NFA1). |
| Immunogen Sequence: | GQAIHSPAPQSPAPSPEGTS TSPAPVTPAAAVPEAPSVTP TAPPEDEDPALSPHLLLPDS LSQLEEFGRQRKWHKRQSTH QRPRQFNDLWVRIEDSTTAS PPPLPLQPTHSSGTAKPPFQ LSDQLQQQDPPGPASS |
| Function | Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation. |
| Protein Name | Metalloprotease Tiki2Heart - Kidney And Adipose-Enriched Transmembrane Protein HomologTrab Domain-Containing Protein 2b |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Metalloprotease Tiki2 antibodyAnti-Heart - Kidney And Adipose-Enriched Transmembrane Protein Homolog antibodyAnti-Trab Domain-Containing Protein 2b antibodyAnti-TRABD2B antibodyAnti-HKAT antibodyAnti-TIKI2 antibody |
Information sourced from Uniprot.org