• Immunofluorescence analysis of PC-12 cells using TRA2B Rabbit polyclonal antibody (STJ11105760) at dilution of 1:50 (40x lens). Blue: DAPI for nuclear staining.
  • Immunofluorescence analysis of HeLa cells using TRA2B Rabbit polyclonal antibody (STJ11105760) at dilution of 1:50 (40x lens). Blue: DAPI for nuclear staining.
  • Western blot analysis of various lysates, using TRA2B antibody (STJ11105760) at 1:900 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 20s.

Anti-TRA2B antibody (STJ11105760)

SKU:
STJ11105760-20

£146.50
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Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Transformer-2 Protein Homolog Beta is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TRA2B
Gene ID: 6434
Uniprot ID: TRA2B_HUMAN
Immunogen: A synthetic peptide of human TRA2B
Tissue Specificity Highest expression in heart, skeletal muscle and pancreas. Less abundant in kidney, placenta and brain. Lowest expression in kidney and liver.
Post Translational Modifications Phosphorylated in the RS domains. Dimethylation at Arg-241 is probably asymmetric.
Function Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA.
Protein Name Transformer-2 Protein Homolog Beta
Tra-2 Beta
Tra2-Beta
Htra2-Beta
Splicing Factor - Arginine/Serine-Rich 10
Transformer-2 Protein Homolog B
Database Links Reactome: R-HSA-72163
Reactome: R-HSA-72203
Reactome: R-HSA-9013418
Reactome: R-HSA-9013422
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Transformer-2 Protein Homolog Beta antibody
Anti-Tra-2 Beta antibody
Anti-Tra2-Beta antibody
Anti-Htra2-Beta antibody
Anti-Splicing Factor - Arginine/Serine-Rich 10 antibody
Anti-Transformer-2 Protein Homolog B antibody
Anti-TRA2B antibody
Anti-SFRS10 antibody

Information sourced from Uniprot.org

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